Synergistic effects of combination antibiotics on E. coli biofilms
Public source linkedResearch
Inspect PosterMaya Chen
Aspiring computational biologist
Biology student researching antibiotic resistance
Seattle, WA
I'm a junior at Lincoln High School studying how bacterial biofilms respond to combination antibiotic therapies. I want to use computational tools to make drug discovery faster and cheaper.
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Regional Science Fair, 1st Place in Microbiology
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Inspect Fictional demo award recordAbout
I split my time between a university wet lab and my laptop, building models of bacterial growth.
Interested in
- Microbiology
- Bioinformatics
- Public health
Currently working on
- A biofilm growth model in Python
- ISEF regional submission
Looking for
- Summer research programs
- Lab internships
Research
Synergistic effects of combination antibiotics on E. coli biofilms
University of Washington, Mougous Lab · Jun 2025 - Present · Mentor: Dr. Sarah Kim
Public source linked
Abstract
Investigated whether sub-inhibitory combinations of ampicillin and tetracycline disrupt biofilm formation more effectively than either antibiotic alone.
Methods
Grew E. coli biofilms in 96-well plates, treated with antibiotic combinations, and quantified biomass with crystal violet staining across 240 samples.
Results
Combination treatment reduced biofilm biomass 38% more than the best single antibiotic at equivalent total dose.
Aseptic techniqueData analysisPythonScientific writing
Proof card
What I did: Ran biofilm assays, analyzed crystal violet staining results, and summarized the findings for a science fair submission.
Why it matters: The work connects lab technique with a public health problem that research programs understand quickly.
Impact: Combination treatment reduced biofilm biomass 38% more than the strongest single-antibiotic condition.
Crystal violet stainingPythonImageJExperimental designData analysisScientific writing
Education
Lincoln High School
2023 - 2027 · Seattle, WA
High School Diploma (expected 2027)
Honors: National Honor Society, 4.0 unweighted GPA
AP BiologyAP ChemistryAP Computer Science A
Awards
Regional Science Fair, 1st Place in Microbiology
RegionalPublic source linkedWashington State Science & Engineering Fair · Mar 2025
Selected from 112 projects in the biological sciences division.
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Why it matters: Shows outside validation for the research, not just a self-described project.
Impact: 1st place in the microbiology category.
Skills
Programming
PythonRPandas
Research
Lab techniquesLiterature reviewStatistics
Leadership
Science club president
Tools
BLASTImageJLaTeX
Want to connect?
I'm always open to opportunities and conversations.
Email me
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